NOVASINERGIA//(VOL. 5, NUM. 1)
Volumen: 5, Numero: 1, Páginas: 163-180 pp.
Valproic acid is an anti-seizure drug characterized by increasing brain levels of gamma-aminobutyric acid. Thus, it has been widely used to treat epilepsy and various neurological disorders. However, there are contradictory reports on its hepatotoxic effect. The objective of this work was to analyze the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzymes in patients with neurological disorders treated with valproic acid. Thirty-eight patients treated with valproic acid and 10 individuals without treatment (control group) were studied. Whole blood samples obtained by venipuncture were processed. Aminotransferase levels were determined from the serum obtained by Molecular Absorption Spectrophotometry. The data was processed using the Mann-Whitney tests, Dunnett-ANOVA method to establish the statistical significance of the results. It was determined that there are no statistically significant differences between the serum levels of aminotransferases in both groups (treated with valproic acid and control) and the reference enzyme levels. Therefore, in this exploratory study, the pharmacological action of valproic acid did not reveal the induction of intrinsic or idiosyncratic reactions of importance on hepatic metabolism mediated by aminotransferases in the population studied.
Ácido valproico es un fármaco anticrisis caracterizado por aumentarlos niveles cerebrales del ácido gamma-aminobutírico que ha sido utilizadoampliamente en el tratamiento de epilepsias y diversos trastornos neurológicos.Sin embargo, existen reportes contradictorios sobre su efecto hepatotóxico. Elobjetivo de este trabajo fue analizar los niveles de las enzimas alaninaaminotransferasa (ALT) y aspartato aminotransferasa (AST) en pacientes contrastornos neurológicos tratados con ácido valproico. Se estudiaron 38 pacientestratados con ácido valproico y 10 individuos sin tratamiento (grupo control). Lasmuestras de sangre total obtenidas por punción venosa se procesaron y a partirdel suero obtenido se determinaron los niveles de las aminotrasferasas medianteEspectrofotometría de Absorción Molecular. Los datos se procesaron mediante laspruebas de Mann Whitney, método de Dunnett-ANOVA, para establecer lasignificancia estadística de los resultados. Determinándose, que no existendiferencias estadísticamente significativas entre los niveles séricos de lasaminotransferasas de ambos grupos (tratados con ácido valproico y control) y losniveles enzimáticos de referencia. Por tanto, en este estudio exploratorio la acciónfarmacológica del ácido valproico no reveló la inducción de reacciones intrínsecaso idiosincráticas de importancia sobre el metabolismo hepático mediado por lasaminotransferasas en la población estudiada