Observatorio de Investigación y Desarrollo Tecnológico


  • PHARMACOLOGYONLINE//(VOL. 2)

    Volumen: 2, Numero: 1, Páginas: 13-22 pp.

    COMPOSITION AND ANTIBACTERIAL ACTIVITY OF THE PIPER ERIOPODON (MIQ.) C.DC. ESSENTIAL OIL FROM THE VENEZUELAN ANDES

    Abstract

    The essential oil of the fresh leaves and stems of Piper eriopodon (Piperaceae), was extracted by hydro-distillation, using the Clevenger trap, with a yield of 0.188 percent. Thirty-eight compounds were identified by gas-chromatography, coupled with mass spectrometry (GC-MS). The main components were: 1,8-cineole (37.2 percent), ?-pinene (9.38 percent), myristicin (7.82 percent), ?-pinene (7.27 percent), trans-caryophyllene (5.80 percent) and ?-selinene (4.04 percent). The antibacterial activity assessment was carried out using the disk diffusion agar method technique (Kirby-Bauer). Results showed that the essential oil from the Piper eriopodon showed no antibacterial activity against Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae). In contrast, against Gram-positive bacteria (Staphylococcus aureus, Enterococcus faecalis), it only showed activity against Staphylococcus aureus, determining a Minimum Inhibitory Concentration of 2,500 ?g/mL.


    Keywords


    Piperaceae, Piper eriopodon, antibacterial activity, essential oil


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